The importance of blind trials is to make sure that no
factor varies systematically between the treatment group and
the control group other than the treatment itself. If the
patients know which group they are in, then this knowledge
itself constitutes a systematic difference between the two
groups. This might not seem like an important difference, but
in fact simply believing that you are being treated can have a
measurable effect for a wide range of medical conditions.
Patients who are given a placebo to take often show a
measurable improvement compared to patients who are given
nothing at all. This is called the placebo effect.
Again, the importance here is to rule out any factors
which might vary systematically between the treatment group
and the control group. It has been shown that if the doctor
knows whether the patient is in the treatment group or the
control group, this knowledge can unconsciously alter their
behaviour towards the patient and their perception of the
patient's condition. In this case, if the doctor knows which
group the patient is in, this might unconsciously influence
their perception of slight changes in hair growth or of the
severity of side effects. This makes the data provided by the
doctor less reliable.
No, a controlled trial is unlikely to be possible in
this case. We can't assign people randomly to two groups and
make one group believe in superstitions. Hence the two groups
(superstitious and non-superstitious) are self-selecting, and
this introduces the possibility of bias. It may be that
people with a predisposition to neurosis, depression or low IQ
are more likely to end up in the superstitious group than in
the non-superstitious group. This is why the correlation
reported in the newspaper article does not establish a causal
link.